Karachi is 12 hours ahead of Vancouver
There is no standard 8-to-6 overlap. Someone joins early or late.
For Vancouver and Karachi, the standard workday in one city falls outside office hours in the other — that's what 12 hours of distance does. Keep live syncs short and infrequent, and let written updates carry the day-to-day between Vancouver and Karachi. Just remember Vancouver changes its clocks for daylight saving and Karachi doesn't, so confirm the overlap whenever the seasons turn.