Prague is 4 hours ahead of São Paulo
Best overlap: 8:00 AM to 2:00 PM in São Paulo is 12:00 PM to 6:00 PM in Prague.
Shoot for 8:00 AM to 2:00 PM in São Paulo; your Prague colleagues will see that as 12:00 PM to 6:00 PM. Prague is 4 hours ahead of São Paulo, but with 6 hours of common ground you can hold morning or afternoon meetings without anyone working odd hours. Daylight saving complicates things slightly: Prague observes it, São Paulo doesn't, so the difference flexes by an hour part of the year.