Rome is 4 hours behind Islamabad
Best overlap: 12:00 PM to 6:00 PM in Islamabad is 8:00 AM to 2:00 PM in Rome.
For the smoothest call, aim inside 12:00 PM to 6:00 PM in Islamabad, i.e. 8:00 AM to 2:00 PM in Rome. The overlap is wide at 6 hours, so you can protect mornings for deep work and still find plenty of meeting time. Note that Rome follows daylight saving while Islamabad stays put, so the times above drift by an hour seasonally.