San Diego is 12 hours behind Karachi
There is no standard 8-to-6 overlap. Someone joins early or late.
For Karachi and San Diego, the standard workday in one city falls outside office hours in the other — that's what 12 hours of distance does. Keep live syncs short and infrequent, and let written updates carry the day-to-day between Karachi and San Diego. Heads up: because San Diego changes its clocks and Karachi doesn't, the difference moves by an hour twice a year. Confirm the overlap around the DST switch.