Best overlap: 1:00 PM to 6:00 PM in Karachi is 8:00 AM to 1:00 PM in Manchester.
Shoot for 1:00 PM to 6:00 PM in Karachi; your Manchester colleagues will see that as 8:00 AM to 1:00 PM. Manchester is 5 hours behind Karachi, so you've got a workable 5-hour overlap — ideal for a standing meeting around 1:00 PM in Karachi (8:00 AM in Manchester). Note that Manchester follows daylight saving while Karachi stays put, so the times above drift by an hour seasonally.
London to New York is five hours apart, except for the five weeks a year when it isn't. Exact overlap windows for every US zone, the 2026 DST mismatch dates, and where to put the recurring sync. -